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To describe the safety and efficacy of opicapone, a newly Food and Drug Administration-approved catechol- -methyltransferase (COMT) inhibitor, as an adjunctive treatment to levodopa/carbidopa in patients with Parkinson's disease (PD) experiencing episodes. A literature search through PubMed and International Pharmaceutical Abstracts (January 2000 to October 202 was conducted using the following search terms , and . Articles selected included those describing preclinical and clinical studies examining the pharmacokinetics, efficacy, and/o