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Pharmacological inhibition of caspase-1 strongly reduced DVT in mice, and thrombi that still formed contained no citrullinated histone 3, a marker of NETs. Taken together, these data demonstrate a cross-talk between NETs and inflammasomes both in vitro and in the DVT setting. This may be an important mechanism supporting thrombosis in veins. Whether physical development and rapid growth during the first 2 years of life are associated with puberty onset in girls remains unclear. To examine the associations of infant physical development