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Here, we more improve the bispecific CD4-MBL CAR with the addition of a third targeting moiety against a definite conserved Env determinant, for example. a polypeptide series produced by the N-terminus of this HIV coreceptor CCR5. The trispecific CD4-MBL-R5Nt CAR shows improved in vitro anti-HIV potency compared to the CD4-MBL automobile, in addition to invisible HIV entry receptor task. The large anti-HIV potency associated with CD4-MBL-R5Nt automobile, along with its all-hu
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