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Medication For ADHD - What Are the Side Effects? Many people who suffer from ADHD notice a decrease in symptoms when they use medication. Every person's reaction is different, and the side effects can be a problem. Methylphenidate is part of a class of drugs referred to as stimulants. It works by increasing levels of a substance in the brain that aids in controlling attention and behavior. Stimulant medication Stimulants improve attention and concentration in 70 to the 80% of children and adults who take