https://cxcrsignal.com/index.p....hp/metabolism-multis
In addition, the decreased ratio of LC3II/LC3I along with increased p62 appearance had been seen under reversine therapy, showing the autophagy inhibition by reversine in HepG2 cell line. Furthermore, modulation of autophagy with rapamycin and chloroquine considerably attenuated and improved the cytostatic results of reversine, respectively. Conclusions reversine could lessen the cell viability of HCC cells via inducing cellular apoptosis and polyploidy
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