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viewed journal and will be disseminated in relevant conferences. Inplasy registration number INPLASY202040024.Background Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease with high morbidity and mortality worldwide. Jianpi Yiqi method (JYM) is a classical Chinese therapy in the treatment of COPD. However, there is no systematic review related to JYM for COPD. In this study, we aim to systematically examine the efficacy and safety for clinical use of JYM. Methods and analysis We will conduct a comprehensive