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It may be a viable alternative to the treatment of peripheral precocious puberty in girls. However, further randomized controlled trials are needed. Copyright © 2020 Lili Liu et al.Systemic lupus erythematosus (SLE) is a refractory autoimmune disease. Zhibai Dihuang Wan (ZDW) has frequently been used for treating SLE in China and been proved to have a prominent role in decreasing SLE patients' morality rate. However, the active substances in ZDW and the molecular mechanisms of ZDW in SLE remain unclear. This study identified the bioactiv