https://www.selleckchem.com/pr....oducts/chir-99021-ct
Interestingly, Npy1r mRNA expression was reduced in the ARC and in the paraventricular hypothalamic nuclei of female, but not male mice. These results demonstrated that female mice are resilient to hormonal and metabolic effects of limbic Npy1r gene inactivation, suggesting the existence of an estrogen-dependent relay necessary to ensure the maintenance of the homeostasis, that can be mediated by hypothalamic Y1R.Stimulation of brown adipose tissue (BAT) thermogenesis in humans has emerged as an attractive target to impro