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Positive effects of hyperbaric oxygen on perianal fistulas in Crohn's disease have been reported. To assess efficacy, safety and feasibility of hyperbaric oxygen in Crohn's disease patients with therapy-refractory perianal fistulas. Twenty consecutive patients were recruited at the out-patient fistula clinic of the Amsterdam UMC. Crohn's disease patients with high perianal fistula(s) failing conventional treatment for over 6months were included. Exclusion criteria were presence of a stoma, rectovaginal fistula(s) and recent changes in trea