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INTRODUCTION Duodenopancreatic trauma is rare and presents high morbidity and mortality rates. Pancreaticoduodenectomy (PD) is the only possible treatment indicated for the most complex injuries (grades IV and V). Although, it is commonly a one-stage procedure, damage control surgery corroborates with a two-stage PD performed on unstable trauma victims. OBJECTIVES Compare the mortality rate of one and two-stage PD in trauma patients. MATERIALS AND METHODS A systematic electronic search of PubMed, Elsevier, LILACS, Scielo, and Capes was c