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028 (OR 0.292, 95% CI 0.095-0.901). In addition to CTLA-4, CD28 gene was also a crucial SNP in TR, because there was a signification for the haplotype with Grs3181097 (p = 0.015). Consequently, we suggested that the TR was related to CD28 by regulating the degree of immune response.Thermogravitational convective thermal transmission, inside a square differentially-heated chamber with a nanoliquid, has been examined in the presence of internal adiabatic or a thermally-conducting solid body. A single-phase nanoliquid approach is employed,