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Next, every final model was subjected for strict validation employing the internationally accepted internal and external validation parameters. The proposed models could be applicable for data gap filling to determine hydrolysis half-lives of organic chemicals at different environmental conditions. Generally, presence of aliphatic ether and ether functional groups, high percentage of oxygen content in the molecule and presence of O-Si pairs of atoms at topological distance one, results in a shorter hydrolysis half-life of organic chemicals