https://incb054828inhibitor.co....m/covid-19-rest-stud
In the current research, we employ an endothelium-specific TRPV4 knockout mouse model (ecTRPV4-/-) to recognize and characterize TRPV4-dependent endothelial Ca2+ dynamics. We realize that carotid arteries from both ecTRPV4-/- and WT mice show a range of basal and acetylcholine (ACh)-induced Ca2+ dynamics, comparable in web frequency. Evaluation of discrete Ca2+ event parameters (amplitude, extent, and spread) and occasion composite values shows that while ecTRPV4-/- artery endothelium predominantly produces large Ca2+ ac