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The dwelling of every cross-link identified was elucidated using high performance fluid chromatography (HPLC) hyphenated to tandem size spectrometry (MS/MS) with higher power collisional dissociation (HCD). Moreover, we speculate on the part of amino acids in formulation buffers and their influence on mAb security. We theorize that whilst the adduction of formula buffer amino acids could have a bad effect on product quality, it might proba