https://www.selleckchem.com/pr....oducts/tetrahydropip
Small molecule inhibitors able to bind to gp120 and prevent CD4-induced HIV-1 envelope conformational change provide an important class of inhibitors. Currently, only Fostemsavir is approved for HAART, which makes this class of inhibitors attractive candidates for prevention. We assessed the activity of DS003 (BMS-599793), an analogue of BMS-378806, in different mucosal tissues and elucidated its mechanism of action. Pre-clinical analysis was performed with human mucosal tissue models as surrogates of in vivo activity. Antivi
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