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Here is the first report of pulsus alternans in a critically sick dog just before clinical deterioration and demise. This can be also the very first documentation of pulsus alternans with a high-definition oscillometric product. Crucial clinical message Increased recognition of pulsus alternans and its own prospective ramifications in veterinary medication may contribute to the recognition of cardiovascular complications associated with systemic disease.This instance report describes 2 endurance horses wi