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The present study would be a particularly meaningful strategy to directly engineer cells in vivo for cell-based therapy.The yellow-green emissive poly(9,9-dioctylfluorene-alt-benzothiadiazole) (F8BT) polymer is widely used because of its suitability for a variety of applications. However, we have found that F8BT shows huge performance variations that depend on the chemical supplier, with photoluminescence quantum yields (PLQYs) ranging from 7 to 60% in neat films. Polymers generally face problems including purity, polydispersity, and r