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With regards to executive function, the BD patients performed significantly poorer than the control subjects (P.05). Moreover, the interaction effect between BD diagnosis and HOMA-IR value on the WCST-preservation errors was significant (P=.01), and post-hoc analyses showed that the cognitive abilities were worse in the BD patients with a higher IR than in the others groups. Insulin sensitivity is associated with the neurocognitive performance in euthymic BD patients. Although the underlying mechanisms remain unclear,