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121 (97-128), p less then 0.05), due to impaired filamentous actin organization (% of positive cells 69 (59-77) vs. 92 (88-94), p less then 0.05). To conclude, this study reveals the categories of patients with HHT that are prone to immunosuppression and require careful monitoring, and suggests a potential therapeutic strategy based on the functional activation of neutrophils.The use of recombinant endolysins is a promising approach for antimicrobial therapy capable of counteracting the spread of antibiotic-resistant strains. To obtain the