https://www.selleckchem.com/pr....oducts/dubs-in-1.htm
Ewing sarcoma is an aggressive bone cancer of children and young adults defined by the presence of a chromosomal translocation t(11;22)(q24;q12). The encoded protein, EWS/FLI, fuses the amino-terminal domain of EWS to the carboxyl-terminus of FLI. The EWS portion is an intrinsically disordered transcriptional regulatory domain, while the FLI portion contains an ETS DNA-binding domain and two flanking regions of unknown function. Early studies using non-Ewing sarcoma models provided conflicting information on the roles of each domain o
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