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Furthermore, the reduced susceptibility to itraconazole and voriconazole was overcome by milbemycin oxime. In conclusion, our study shed more light on the role of the ABC transporter family in T. mentagrophytes, which, if overexpressed, can confer resistance to single azole drugs and even cross-resistance. Finally, milbemycin oxime could be an interesting compound supporting treatment with azole drugs in the case of refractory dermatomycoses. In conclusion, our study shed more light on the role of the ABC transporter family in T. mentagro