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The purpose of this review is to examine the current literature exploring the role of glutamatergic transmission in the DVC in the regulation of GI functions.A recently reported coupled-perturbed Kohn-Sham implementation to compute nuclear shielding constants with gauge-including atomic orbitals and local hybrid functionals has been extended to cover higher derivatives of the density in the local mixing function (LMF) of the local hybrid as well as the calibration function (CF) needed to deal with the ambiguity of exchange-energy densi
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