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89-fold increased risk of inhibitor development. In conclusion, our study supports the protective effect of O blood type on inhibitor risk in severely affected hemophilia A patients.This study aimed to determine the impact of major hemorrhage (MH) protocol (MHP) activation on blood administration and patient outcome at a UK major cardiothoracic center. MH was defined in patients ( 16 years) as those who received 5 units of red blood cells (RBCs) in 10 units in 24 hours. Data were collected retrospectively from patient electro