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Hepatitis delta virus (HDV) is a defective RNA virus requiring the clear presence of the hepatitis B virus area antigen (HBsAg) to complete its life pattern. HDV infects hepatocytes using the hepatitis B virus (HBV) receptor, the sodium taurocholate cotransporting polypeptide (NTCP). The HDV genome is a circular single-stranded RNA which encodes for a single hepatitis delta antigen (HDAg) that exists in two kinds (S-HDAg and L-HDAg), as well as its replication is mediated by the number RNA polymer