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We report the clinical course as much as September 2019 inside our client, and compare the HBV mutations to those of the two Korean patients. Four mutations (rtS106C, rtD134N/S[N/S], rtM204V, and rtL269I) plus ETV resistance (rtL180M and rtS202G) existed when she created viral breakthrough during ETV and TDF combo treatment in April 2013. Furthermore, three mutations (rtS106C, rtD134N, and rtL269I) existed at standard. Our patient's dad is Korean. Considering these factors, patients with your three or four