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05). Associations of PU.1 mRNA expression in CD4+T cells with major clinical and laboratory parameters of SLE patients were also analyzed, but no significant correlations were found. Consistent with previous studies, SLE patients had increased IL-1β, IL-18, IL-6, IFN-α, TNF-α and IL-10 plasma concentrations than HC (P less then 0.01). The expression level of plasma TGF-β1 was significantly decreased in SLE patients than in HC (P less then 0.001). In SLE patients, the expression level of IL-1β was positive correlated with PU.1 mRNA