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Compared to the hdc gene from P. kishitanii, expression of the hdc2 gene was constitutive and not affected by pH or excess histidine. This newly identified protein explains possible mechanisms of histamine production in P. phosphoreum. Characterization of this protein will help in designing control measures to prevent or reduce histamine production in fish.Effect of functionalization on stability, solubility, and plasmonic features of gold nanoparticle with the general formula of Au18(SR)14 in water solvent has been studied in this work.