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Soft tissue involvement (STI) indicates poor prognosis in nasopharyngeal carcinoma (NPC). However, only a few studies have systematically assessed this extension using network analysis. To investigate the prognostic value of STI and to propose an improved STI grading system for NPC therapy. Retrospective study. A total of 1225 consecutive patients with pathologically confirmed NPC treated with intensive-modulated radiotherapy from January 2010 to March 2014 were enrolled from two centers. T1- and T2-weighted imaging and enhanced T1-weig