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We showed that in models of autoimmunity and transplant rejection, adoptive transfer of antigen specific 3C-iTregs prevented the induction of EAE and enabled long-term skin allograft survival. Our data demonstrate that the Foxp3 locus can be epigenetically edited ex vivo to generate stable therapeutic iTregs. This article is protected by copyright. All rights reserved.Interactions between biomolecules control the processes of life in health, and their malfunction in disease, making their characterization and quantification essential. Imm
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