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ADHD Stimulant Medication Around 70% to 80% children and adults with ADHD benefit from stimulants. They reduce symptoms by increasing dopamine and norepinephrine levels. These medicines start working in 30 to 45 minutes and last between 3 and 6 hours. The medicines are available in chewable or liquid tablet form. Nonstimulant drugs may be prescribed by your doctor to complement stimulants. Thes