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In recent years, the role of circular RNAs (circRNAs) in tumors has attracted widespread attention. Some circRNAs have been reported to play a role in triple negative breast cancer (TNBC), however, circRNAs have rarely been reported in terms of TNBC resistance. This study aimed to clarify that circGFRA1 affects the sensitivity of TNBC cells to paclitaxel (PTX) by the miR-361-5p/TLR4 pathway. Compared with the non-PTX-resistant TNBC cell line MDA-MB-231, the expression of circGFRA1 in the PTX-resistant TNBC cell line MDA-MB-231.PR was s