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Sbds-/- mice are embryonic life-threatening. Utilizing CRISPR/Cas9 editing, we produced sbds-deficient zebrafish strains. Sbds protein levels progressively decreased and became undetectable at 10 times postfertilization (dpf). Polysome evaluation revealed decreased 80S ribosomes. Homozygous mutant fish created typically until 15 dpf. Mutant seafood later had stunted development and revealed signs of atrophy in pancreas, liver, and intestine. In inclusion, neutropenia happened by 5 dpf. Upregulatio
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