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In this context, we have employed coarse-grained molecular dynamics simulation techniques to shed light on the supramolecular characteristics of dendrimer-siRNA complexation, the so-called dendriplex formations. Our data provide important information on self-assembly dynamics driven by surface chemistry and competition mechanisms. Copyright © 2020 American Chemical Society.Radiation-induced intestinal injury is a common complication of abdominal radiation therapy. However, the pathological features of radiation-i