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Significant loss of mean RNFL (from 100.79±16.05μm to 89.96±13.79μm) and GCIPL thickness (from 83.1±5.60μm to 79.85±6.45μm) was observed at 6months (p=0.001 for both). Patients with subclinical toxicity had significantly greater damage in temporal RNFL quadrant, supero-nasal and infero-nasal GCIPL sectors compared with others. The incidence of clinical EMB optic neuropathy was 2%, though subclinical damage in the form of increase in VER latency, and decrease in RNFL and GCIPL on OCT was seen in 46% eyes. The incidence of clinical EM
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