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In this study, the mNSS test revealed that L-lactate preconditioning alleviates the neurological deficit due to TBI in rats. L-lactate preconditioning somewhat increased the appearance of GPR81, PSD95, GAP43, BDNF, and MCT2 24 h after TBI into the cortex and hippocampus weighed against the sham team. Taken collectively, these information proposed that L-lactate preconditioning is an efficient technique with which to recuperate neurological function after T