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How Does Medication For ADHD Work? The most common medications that doctors prescribe to treat ADHD are effective by increasing the levels of the chemicals dopamine and norepinephrine inside the brain. They are available in short-acting and extended-release formulations. The effects of medications vary for everyone and it can take some time to determine the appropriate dosage and medicine for you or your child. Lifestyle changes can help alleviate symptoms, as can medications. Methylphenidate Methylphenidate is a stimulant for the cen