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The cell proliferation, invasion, migration, cell cloning, and cell cycle were affected after reducing expression. Our data suggest that either or PTHrP plays a key role in the malignant transformation of oral leukoplakia and might be a reliable biomarker for predicting the carcinogenesis of oral leukoplakia. Our data suggest that either PTHLH or PTHrP plays a key role in the malignant transformation of oral leukoplakia and might be a reliable biomarker for predicting the carcinogenesis of oral leukoplakia. DNA methylation plays an importa