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How Does Medication For ADHD Work? Stimulants boost the levels of norepinephrine and dopamine in your brain, which can improve attention and impulse control. They are available in immediate-release (short-acting) and extended-release tablets taken once a day, typically in the morning. Nonstimulant drugs have a longer time to work, but they can improve attention and impulse control. Atomoxetine, Viloxazine and guanfacine are antidepressants that incr