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Emodin exhibits antioxidative features in the central nervous system (CNS); however, its neuroprotective method against fluoride remains to be elucidated. Our aim was to explore the neuroprotective efficacy and the possible components of emodin. In our study, synaptic proteins and oxidative stress harm were analyzed after human being neuroblastoma SH-SY5Y cells were addressed with a high doses of NaF for 24 hours. Furthermore, pretreatment with emodin had been used to highlight