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81, p less then 0.01), and (ii) alpha-amylase- and cortisol-changes during 2nd halftime (Pearson's r 0.76, p less then 0.05). The results indicated specific dynamics of biomarkers during the handball match, with significant increase in alpha-amylase during the entire match and significant increase in the testosterone level during the first half of the match. Further studies are needed to evaluate the associations between real-game performance and changes in hormonal responses.Background The metastasis-associated lung adenocarcinoma transc