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The relationship between ventricular pre-excitation and left ventricular dysfunction has been described in the absence of sustained supraventricular tachycardia in a series of case reports. However, there have been no systematic studies about the effect of ventricular pre-excitation on cardiac function in adult patients with different accessory pathway locations. Patients were divided into four groups based on the type and location of their accessory pathway septal, right free wall, left free wall, and concealed. N-terminal pro-B-type n