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ADHD Treatment For Adults Stimulants such as methylphenidate, amphetamine and various brain chemicals can help increase levels. Non-stimulants such as atomoxetine and antidepressants work slower than stimulants, but they could be just as beneficial. Comorbid conditions can alter the effectiveness of ADHD medication. Physicians should address the most severe symptoms of any co-occurring disorder first, and then check to see if the ADHD symptoms improve. Medication Adults with ADHD are typically treat