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Minimum alveolar concentration (MAC) of volatile anesthetic agents to maintain bispectral index (BIS) below 50 in 50% of patients was defined as MACBIS50. The primary objective of this study was to determine the minimum alveolar concentration of sevoflurane as a single hypnotic agent to maintain BIS below 50 in patients during normothermic cardiopulmonary bypass. Prospective and observational study. Dante Pazzanese Institute of Cardiology, Brazil. Eighteen consecutive patients scheduled for elective coronary artery bypass grafting (CABG
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