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etastasis in CRC. Pancreatic cancer is one of the most lethal human cancers. N -methyladenosine (m A), a common eukaryotic mRNA modification, plays critical roles in both physiological and pathological processes. However, its role in pancreatic cancer remains elusive. LC/MS was used to profile m A levels in pancreatic cancer and normal tissues. Bioinformatics analysis, real-time PCR, immunohistochemistry, and western blotting were used to identify the role of m A regulators in pancreatic cancer. The biological effects of methyltransferase-l