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Based on orthogonal Latin cubes, an image cryptosystem with confusion-diffusion-confusion cipher architecture has been proposed recently (Inf. Sci.2019, 478, 1-14). However, we find that there are four fatal vulnerabilities in this image cryptosystem, which leave open doors for cryptanalysis. In this paper, we propose a reference-validation inference algorithm and design screening-based rules to efficiently break the image cryptosystem. Compared with an existing cryptanalysis algorithm, the proposed method requires fewer pairs of chosen
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