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Measures of precision were reported for 63% of effect measures (541/852). CONCLUSION Many aspects of the design, methods, analysis and reporting of ITS studies can be improved, particularly description of the statistical methods, and approaches to adjust for and estimate autocorrelation. More guidance on the conduct and reporting of ITS studies is needed to improve this study design. Accumulation of oxidative stress in cells is an essential feature of cellular senescence and aging. This phenomenon is involved in different age-related di
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