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Moreover, NE and smoking or inactive physical activity exhibited an excess risk of high C-Ca (RERI 0.47, 95% CI 0.09-0.85 for smoking or RERI 0.46, 95% CI 0.01-0.90 and AP 0.51, 95% CI 0.03-0.99 for physical activity). Our study suggests that CKD patients who were enrolled in the NE program had better kidney function. Thus, NE could be associated with slowing kidney function decline and improving cardiovascular risk factors.Stochastic resonance (SR), a typical randomness-assisted signal processing method, has been extensively studied in