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We report a rare case of absolute thrombocytopenia with ticagrelor after 6 h of single loading dose of ticagrelor. -year-old male with ischaemic cardiomyopathy, hypertension, and dyslipidaemia presented with chest pain. He was found to be in new-onset atrial flutter and ruled in for a non-ST-segment elevation myocardial infarction. An echocardiogram showed decreased left ventricular ejection fraction, estimated at 15-20% and serum troponin peaked at 0.2 ng/dL, baseline platelet count was 203 × 10 /µL. He underwent a drug-eluting stent