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These findings indicate that CY-09 may represent an important treatment agent for epilepsy and other NLRP3 inflammasome-associated diseases. Nummular eczema may mimic diseases that present with annular configuration and the differential diagnosis is broad. This article aimed to provide an update on the evaluation, diagnosis, and treatment of nummular eczema. A PubMed search was performed in using the key terms "nummular eczema", "discoid eczema", OR "nummular dermatitis". The search strategy included meta-analyses, randomized controlle