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In our study we aimed to analyze sleep variability and activity in patients with cystic fibrosis (CF) during their hospital stay. Forty-three CF patients were recruited and have been divided into two subgroups exacerbated (n=18) and non-exacerbated (n=25). During the course of their hospital stay we used VitaLog, a minimal-impact biomotion device, in order to determine total sleep time (TST), time in bed (TI, sleep efficiency (SE) and intra patient standard deviation (IPSD) of TST. TST was 5.1h±1.5h and ranged from 0.6h to 7.9